Febrile neutropenia in acute leukemia. Epidemiology, etiology, pathophysiology and treatment

BA Hansen, Ø Wendelbo, Ø Bruserud… - … of hematology and …, 2019 - pmc.ncbi.nlm.nih.gov
Acute leukemias are a group of aggressive malignant diseases associated with a high
degree of morbidity and mortality. An important cause of both the latter is infectious …

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

LE Montefiori, S Bendig, Z Gu, X Chen, P Pölönen… - Cancer discovery, 2021 - AACR
Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …

Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia

A Porwit, MC Béné - Cytometry Part B: Clinical Cytometry, 2019 - Wiley Online Library
Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias
with a poor prognosis. Proper diagnosis and classification of MPAL is extremely important …

[HTML][HTML] Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia

R Mulet-Lazaro, S van Herk, M Nuetzel… - Nature …, 2024 - nature.com
Leukemias with ambiguous lineage comprise several loosely defined entities, often without
a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of …

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation

JS Duke-Cohan, A Akitsu, RJ Mallis, CM Messier… - Nature, 2023 - nature.com
Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs
in the thymus,,–. Signalling through the pre-T cell receptor (preTCR), a CD3-associated …

Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia …

GY Lee, SY Jeong, HR Lee, IH Oh - Scientific Reports, 2019 - nature.com
The bone marrow (BM) microenvironment serves as a stem cell niche regulating the in vivo
cell fate of normal hematopoietic stem cells (HSC) as well as leukemia stem cells (LSCs) …

Multicenter retrospective analysis of clinical outcome of adult patients with mixed-phenotype acute leukemia treated with acute myeloid leukemia–like or acute …

D Lazzarotto, I Tanasi, A Vitale, M Piccini… - Annals of …, 2023 - Springer
Mixed-phenotype acute leukemia (MPAL) is a rare disease. Treatment is often similar to that
of acute lymphoblastic leukemia (ALL), but the outcome in adults and the role of allogeneic …

Management of ALL in adults: 2024 ELN recommendations from a European expert panel

N Gökbuget, N Boissel, S Chiaretti, H Dombret… - Blood, 2024 - ashpublications.org
Abstract Experts from the European Leukemia Net (ELN) working group for adult acute
lymphoblastic leukemia have identified an unmet need for guidance regarding management …

[HTML][HTML] Early T-cell precursor acute lymphoblastic leukemia and T/myeloid mixed phenotype acute leukemia possess overlapping characteristics and both benefit …

S Liu, Q Cui, H Dai, B Song, W Cui, S Xue, H Qiu… - … and Cellular Therapy, 2021 - Elsevier
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and T-lymphoid/myeloid
mixed phenotype acute leukemia (T/M-MPAL) are closely related entities and remain a …

Update on acute leukemias of ambiguous lineage

N Aggarwal, OK Weinberg - Clinics in laboratory medicine, 2021 - labmed.theclinics.com
Acute leukemia of ambiguous lineage (ALAL) either shows no commitment to either the
myeloid B-lymphoid or T-lymphoid lineages (acute undifferentiated leukemia [AUL]) or …