Assays and technologies for developing proteolysis targeting chimera degraders
Targeted protein degradation by small-molecule degraders represents an emerging mode of
action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules …
action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules …
Fluorescence sensing of circulating diagnostic biomarkers using molecular probes and nanoparticles
O Tagit, N Hildebrandt - ACS sensors, 2017 - ACS Publications
The interplay of photonics, nanotechnology, and biochemistry has significantly improved the
identification and characterization of multiple types of biomarkers by optical biosensors …
identification and characterization of multiple types of biomarkers by optical biosensors …
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
Phosphorylation of the N‐terminal domain of the huntingtin (HTT) protein has emerged as
an important regulator of its localization, structure, aggregation, clearance and toxicity …
an important regulator of its localization, structure, aggregation, clearance and toxicity …
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
I Al-Ramahi, SSP Giridharan, YC Chen, S Patnaik… - elife, 2017 - elifesciences.org
The discovery of the causative gene for Huntington's disease (HD) has promoted numerous
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation
C Cariulo, L Azzollini, M Verani… - Proceedings of the …, 2017 - National Acad Sciences
Posttranslational modifications can have profound effects on the biological and biophysical
properties of proteins associated with misfolding and aggregation. However, their detection …
properties of proteins associated with misfolding and aggregation. However, their detection …
The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract
Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1)
leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains …
leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains …
A toxic mutant huntingtin species is resistant to selective autophagy
Y Fu, P Wu, Y Pan, X Sun, H Yang, M Difiglia… - Nature chemical …, 2017 - nature.com
Protein misfolding is a common theme in neurodegenerative disorders including
Huntington's disease (HD). The HD-causing mutant huntingtin protein (mHTT) has an …
Huntington's disease (HD). The HD-causing mutant huntingtin protein (mHTT) has an …
Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models
M Yu, Y Fu, Y Liang, H Song, Y Yao, P Wu, Y Yao… - Cell Research, 2017 - nature.com
Most neurodegenerative disorders are associated with accumulation of disease-relevant
proteins. Among them, Huntington disease (HD) is of particular interest because of its …
proteins. Among them, Huntington disease (HD) is of particular interest because of its …
The polyglutamine expansion at the N-terminal of Huntingtin protein modulates the dynamic configuration and phosphorylation of the C-terminal HEAT domain
The polyQ expansion in huntingtin protein (HTT) is the prime cause of Huntington's disease
(HD). The recent cryoelectron microscopy (cryo-EM) structure of HTT-HAP40 complex …
(HD). The recent cryoelectron microscopy (cryo-EM) structure of HTT-HAP40 complex …
Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models
M Daldin, V Fodale, C Cariulo, L Azzollini, M Verani… - Scientific reports, 2017 - nature.com
Conformational changes in disease-associated or mutant proteins represent a key
pathological aspect of Huntington's disease (HD) and other protein misfolding diseases …
pathological aspect of Huntington's disease (HD) and other protein misfolding diseases …