TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein
isoforms through multiple mechanisms including extensive alternative mRNA splicing …

p63 and p73, the two other members of the p53 family, were identified almost 15 years ago.
Here, we review their potential use for diagnosis, prognosis and prediction of response to …

The p53-family member TAp73 is a transcription factor that plays a key role in many
biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a …

Microglia play important roles in the damaged or degenerating adult nervous system.
However, the role of microglia in embryonic brain development is still largely …

The olfactory epithelium is a sensory neuroepithelium that supports adult neurogenesis and
tissue regeneration following injury, making it an excellent model for investigating neural …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …

Abstract Chromosome 16p13. 11 microduplication is a risk factor associated with various
neurodevelopmental disorders such as attention-deficit/hyperactivity disorder, intellectual …

The impairment of apoptotic pathways represents an efficient mechanism to promote
chemoresistance in cancer cells. We previously showed that in epithelial ovarian cancer …

Abstract p73, a transcription factor of the p53 family, plays a key role in many biological
processes including neuronal development. Indeed, mice deficient for both TAp73 and …

Increasing evidence suggests that deficits in adult stem cell maintenance cause aberrant
tissue repair and premature aging [1]. While the mechanisms regulating stem cell longevity …