Among inorganic materials, divalent cations modulate thousands of physiological processes
that support life. Their roles in protein assembly and aggregation are less known, although …

Percutaneous image-guided oncologic interventions have rapidly evolved over the last two
decades as an independent strategy or used within a first-, second-, or even third-line …

Despite advances in the development of targeted therapies for acute myeloid leukemia
(AML), most patients relapse. For that reason, it is still necessary to develop novel therapies …

Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD)
and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been engineered to …

The possibility to conjugate tumor-targeted cytotoxic nanoparticles and conventional
antitumoral drugs in single pharmacological entities would open a wide spectrum of …

Simple Summary The fact that most endometrial cancer (EC) patients overexpress the
CXCR4 receptor in tumor tissue, especially at incurable advanced stages, opens an avenue …

Simple Summary Aimed at minimizing side toxicities cancer therapies require appropriate
functional vehicles at the nanoscale, for receptor-mediated tumor-targeted drug delivery …

Protein-based materials intended as nanostructured drugs or drug carriers are progressively
gaining interest in nanomedicine, since their structure, assembly and cellular interactivity …

CXCR4 is a cytokine receptor used by HIV during cell attachment and infection.
Overexpressed in the cancer stem cells of more than 20 human neoplasias, CXCR4 is a …

Under the need for new functional and biocompatible materials for biomedical applications,
protein engineering allows the design of assemblable polypeptides, which, as convenient …