Acute kidney injury and adverse renal events in patients receiving SGLT2-inhibitors: a systematic review and meta-analysis

J Menne, E Dumann, H Haller, BMW Schmidt - PLoS medicine, 2019 - journals.plos.org
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent a new class of
oral hypoglycemic agents used in the treatment of type 2 diabetes mellitus. They have a …

Antihypertensive and renal mechanisms of SGLT2 (sodium-glucose linked transporter 2) inhibitors

CS Wilcox - Hypertension, 2020 - Am Heart Assoc
Empaglifolzin, canagliflozin, and dapagliflozin are SGLT2 (sodium-glucose linked
transporter type 2) inhibitors for treatment of type 2 diabetes mellitus that also reduce blood …

Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways

R Hasan, S Lasker, A Hasan, F Zerin, M Zamila… - Scientific reports, 2020 - nature.com
The antidiabetic drug canagliflozin is reported to possess several cardioprotective effects.
However, no studies have investigated protective effects of canagliflozin in isoprenaline …

Sodium–glucose cotransporters: functional properties and pharmaceutical potential

R Sano, Y Shinozaki, T Ohta - Journal of Diabetes Investigation, 2020 - Wiley Online Library
Glucose is the most abundant monosaccharide, and an essential source of energy for most
living cells. Glucose transport across the cell membrane is mediated by two types of …

Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury

AR Aroor, NA Das, AJ Carpenter, J Habibi, G Jia… - Cardiovascular …, 2018 - Springer
Background Arterial stiffness is emerging as an independent risk factor for the development
of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which …

[PDF][PDF] RETRACTED ARTICLE: Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO …

P Li, SNA Bukhari, T Khan, R Chitti… - International journal …, 2020 - Taylor & Francis
Li P, Bukhari SNA, Khan T, et al. Int J Nanomedicine. 2020; 15: 9115–9124. The Editor and
Publisher of International Journal of Nanomedicine wish to retract the published article …

Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review

X Xie, C Wu, Y Hao, T Wang, Y Yang, P Cai… - Frontiers in …, 2023 - frontiersin.org
Diabetes is a chronic metabolic disease, and its therapeutic goals focus on the effective
management of blood glucose and various complications. Drug combination therapy has …

Revisiting experimental models of diabetic nephropathy

A Giralt-López, M Molina-Van den Bosch… - International journal of …, 2020 - mdpi.com
Diabetes prevalence is constantly increasing and, nowadays, it affects more than 350 million
people worldwide. Therefore, the prevalence of diabetic nephropathy (DN) has also …

SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na+ transport in Dahl SS rats

O Kravtsova, R Bohovyk, V Levchenko… - American Journal …, 2022 - journals.physiology.org
Na+-glucose cotransporter-2 (SGLT2) inhibitors are the new mainstay of treatment for
diabetes mellitus and cardiovascular diseases. Despite the remarkable benefits, the …

The nicotinamide/streptozotocin rodent model of type 2 diabetes: Renal pathophysiology and redox imbalance features

LJ Yan - Biomolecules, 2022 - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …