Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes
(T2D) results from inadequate β cell mass and function that can no longer compensate for …

The shortage of organs and cells from deceased individuals continues to restrict
allotransplantation. Pigs could provide an alternative source of tissue and cells but the …

The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …

Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine.
These materials are being designed to create environments that promote regeneration …

Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D).
Currently, clinical islet transplantation is limited by allo-and autoimmunity that may cause …

Background: The long‐term viability and function of transplanted encapsulated neonatal
porcine islets was examined in a diabetic patient. Methods and results: A 41‐yr‐old …