Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Multi-omic single-cell datasets, in which multiple molecular modalities are profiled within the
same cell, offer an opportunity to understand the temporal relationship between epigenome …

INTRODUCTION The cerebral cortex is a cellularly heterogeneous structure whose
neuronal circuits underlie high-order cognitive and sensorimotor information processing …

We performed RNA sequencing on 40,000 cells to create a high-resolution single-cell gene
expression atlas of developing human cortex, providing the first single-cell characterization …

How the rich variety of neurons in the nervous system arises from neural stem cells is not
well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover …

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …

The neocortex varies in size and complexity among mammals due to the tremendous
variability in the number and diversity of neuronal subtypes across species. The increased …

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of
the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein …