In situ nucleic acid sequencing of expanded biological samples
The invention provides in situ nucleic acid sequencing to be conducted in biological
specimens that have been physically expanded. The invention leverages the techniques for …
specimens that have been physically expanded. The invention leverages the techniques for …
Nucleic acid sequencing
T Hauling, M Kühnemund - US Patent 11,352,667, 2022 - Google Patents
A nucleic acid sequencing method involving contacting a spatially defined target nucleic
acid sequence with N labeled oligonucleotide probes and performing measurements, at …
acid sequence with N labeled oligonucleotide probes and performing measurements, at …
Spatially distinguished, multiplex nucleic acid analysis of biological specimens
J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …
providing a solid support comprising different nucleic acid probes that are randomly located …
Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
The present invention relates to a method for amplifying at least one target RNA in a fixed
and, optionally, expanded biological sample. In an embodiment of the invention, the method …
and, optionally, expanded biological sample. In an embodiment of the invention, the method …
Protein retention expansion microscopy
The invention provides a method termed protein retention ExM (proExM), in which proteins,
rather than labels, are anchored to the swellable gel, using a cross-linking molecule. This …
rather than labels, are anchored to the swellable gel, using a cross-linking molecule. This …
Iterative expansion microscopy
The present invention leverages the techniques for expansion microscopy (ExM) to provide
improved high-throughput super-resolution whole-organ imaging methodology to image …
improved high-throughput super-resolution whole-organ imaging methodology to image …
Methods for preparing high-resolution spatial arrays
FA Bava - US Patent 12,110,541, 2024 - Google Patents
Provided herein are methods of preparing a spatial array and methods for associating
specific sample analytes with spatial locations in the spatial array. Provided herein are …
specific sample analytes with spatial locations in the spatial array. Provided herein are …
In situ ATAC sequencing
The present invention provides methods for analyzing polynucleotides such as genomic
DNA. In some embodiments, the disclosure provides a method for preparing and amplifying …
DNA. In some embodiments, the disclosure provides a method for preparing and amplifying …
Methods and compositions for partitioning a biological sample
FA Bava - US Patent 11,835,462, 2023 - Google Patents
US11835462B2 - Methods and compositions for partitioning a biological sample - Google
Patents US11835462B2 - Methods and compositions for partitioning a biological sample …
Patents US11835462B2 - Methods and compositions for partitioning a biological sample …
Increasing efficiency of spatial analysis in a biological sample
FA Bava - US Patent 11,732,300, 2023 - Google Patents
Disclosed herein are methods of amplifying an analyte in a biological sample using a
bridging oligonucleotide that hybridizes to a captured analyte. The methods disclosed …
bridging oligonucleotide that hybridizes to a captured analyte. The methods disclosed …