The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

Abstract System xc− represents an intriguing target in attempts to understand the
pathological states of the central nervous system. Also called a cystine-glutamate antiporter …

Localized protein synthesis requires assembly and transport of translationally silenced
ribonucleoprotein particles (RNPs), some of which are exceptionally large. Where in the cell …

We conducted a large-scale screen for Drosophila mutants that have structural
abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful …

Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we
examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT2 …

Local control of mRNA translation modulates neuronal development, synaptic plasticity, and
memory formation. A poorly understood aspect of this control is the role and composition of …

Brain-derived neurotrophic factor (BDNF) stimulates local dendritic mRNA translation and is
involved in formation and consolidation of memory. 2 H, 3 H, 6 aH-pyrrolidino [2 ″, 1 ″-3 …

Translational control is a key genetic regulatory mechanism implicated in regulation of cell
and organismal growth and early embryonic development. Initiation at the mRNA 5′ cap …

Mutations in dpix were recovered from a large-scale screen in Drosophila for genes that
control synaptic structure. dpix encodes dPix, a Rho-type guanine nucleotide exchange …

In Drosophila, the larval neuromuscular junction is particularly tractable for studying how
synapses develop and function. In contrast to vertebrate central synapses, each presynaptic …