Photoresponsive small molecule Inhibitors for the remote control of enzyme activity

D Laczi, MD Johnstone… - Chemistry–An Asian …, 2022 - Wiley Online Library
The development of new and effective therapeutics is reliant on the ability to study the
underlying mechanisms of potential drug targets in live cells and multicellular systems. A …

Photoswitchable Carbamazepine Analogs for Non‐Invasive Neuroinhibition In Vivo

L Camerin, G Maleeva, AMJ Gomila… - Angewandte …, 2024 - Wiley Online Library
A problem of systemic pharmacotherapy is off‐target activity, which causes adverse effects.
Outstanding examples include neuroinhibitory medications like antiseizure drugs, which are …

Bioinspired Nano‐Photosensitizer‐Activated Caspase‐3/GSDME Pathway Induces Pyroptosis in Lung Cancer Cells

M Gao, Q Sun, H Zhang, M Liu, R Peng… - Advanced …, 2024 - Wiley Online Library
Noninflammatory apoptosis is transformed into inflammatory pyroptosis by activating
caspase‐3 to lyse gasdermin E (GSDME), and this process can be used as an effective …

Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea

A Garrido-Charles, A Huet, C Matera… - Journal of the …, 2022 - ACS Publications
Artificial control of neuronal activity enables the study of neural circuits and restoration of
neural functions. Direct, rapid, and sustained photocontrol of intact neurons could overcome …