The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Polymyositis and dermatomyositis are inflammatory myopathies that differ in their clinical
features, histopathology, response to treatment, and prognosis. Although their clinical …

As with the treatment of many immune-mediated diseases, managing myositis encompasses
diverse factors, which present a challenge to the physician caring for these patients. The …

The adult and juvenile myositis syndromes, commonly referred to collectively as idiopathic
inflammatory myopathies (IIMs), are systemic autoimmune diseases with the hallmarks of …

Autoimmune diseases develop as a result of chronic inflammation owing to interactions
between genes and the environment. However, the mechanisms by which autoimmune …

Idiopathic inflammatory myopathies (IIM) are a group of chronic, autoimmune conditions
affecting primarily the proximal muscles. The most common types are dermatomyositis (DM) …

Susac syndrome is an immune-mediated, pauci-inflammatory, ischemia-producing,
occlusive microvascular endotheliopathy/basement membranopathy that affects the brain …

The aim of this review was to summarize recent advances in the understanding of the
clinical and autoantibody phenotypes, their associated outcomes and the pathogenesis of …

Interferons are potent antiviral cytokines that modulate immunity in response to infection or
other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) …