The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

Women often have limited access to contraception, and barrier methods have low
acceptance and a high failure rate, mostly due to incorrect use, which can result in …

The past decade has witnessed the accelerating development of immunotherapies for
cancer treatment. Immune checkpoint blockade therapies and chimeric antigen receptor …

Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Transdermal drug delivery offers a number of advantages for the patient, due not only its non-
invasive and convenient nature, but also factors such as avoidance of first pass metabolism …

Despite recent advances in melanoma treatment through the use of anti-PD-1 (aPD1)
immunotherapy, the efficacy of this method remains to be improved. Here we report an …

Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and
prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF …

A glucose-responsive “closed-loop” insulin delivery system mimicking the function of
pancreatic cells has tremendous potential to improve quality of life and health in diabetics …

The use of microneedles has facilitated the painless localized delivery of drugs across the
skin. However, their efficacy has been limited by slow diffusion of molecules and often …