Non-viral vectors in gene therapy: recent development, challenges, and prospects

H Zu, D Gao - The AAPS journal, 2021 - Springer
Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …

Gold nanoparticles supported by amino groups on the surface of magnetite microspheres for the catalytic reduction of 4-nitrophenol

M Ma, Y Yang, W Li, R Feng, Z Li, P Lyu… - Journal of materials …, 2019 - Springer
Abstract Fe 3 O 4/P (GMA-DVB)/PAMAM/Au microspheres are fabricated to research the
catalytic performances to 4-nitrophenol. In the preparation process, Fe 3 O 4 microspheres …

Peptide dendrimers as valuable biomaterials in medical sciences

FST Mirakabad, MS Khoramgah, K Keshavarz… - Life sciences, 2019 - Elsevier
Peptides are oligomers of amino acids, which have been used in a wide range of
applications, particularly in medical and pharmaceutical sciences. Linear peptides have …

The impact of using single atomistic long-range cutoff schemes with the GROMOS 54A7 force field

TFD Silva, D Vila-Viçosa, PBPS Reis… - Journal of chemical …, 2018 - ACS Publications
With the recent increase in computing power, the molecular modeling community is now
more focused on improving the accuracy and overall quality of biomolecular simulations. For …

NMR studies of excluded volume interactions in peptide dendrimers

NN Sheveleva, DA Markelov, MA Vovk… - Scientific reports, 2018 - nature.com
Peptide dendrimers are good candidates for diverse biomedical applications due to their
biocompatibility and low toxicity. The local orientational mobility of groups with different …

Comparison of Structure and Local Dynamics of Two Peptide Dendrimers with the Same Backbone but with Different Side Groups in Their Spacers

SE Mikhtaniuk, VV Bezrodnyi, OV Shavykin, IM Neelov… - Polymers, 2020 - mdpi.com
In this paper, we perform computer simulation of two lysine-based dendrimers with Lys-2Lys
and Lys-2Gly repeating units. These dendrimers were recently studied experimentally by …

SCF Theory of Uniformly Charged Dendrimers: Impact of Asymmetry of Branching, Generation Number, and Salt Concentration

OV Shavykin, IM Neelov, OV Borisov… - …, 2020 - ACS Publications
Polyelectrolyte dendrimers attract large interest and find multiple applications in many fields.
The majority of theoretical and simulation works consider dendrimers with symmetrical …

Dendrimers: smart nanoengineered polymers for bioinspired applications in drug delivery

K Jain - Biopolymer-based composites, 2017 - Elsevier
Dendrimers have attracted growing attention in the field of drug delivery as smart
nanoengineered polymers. They are defined as novel three-dimensional polymers with …

Why the orientational mobility in arginine and lysine spacers of peptide dendrimers designed for gene delivery is different?

VV Bezrodnyi, OV Shavykin, SE Mikhtaniuk… - International Journal of …, 2020 - mdpi.com
New peptide dendrimer with Lys-2Arg repeating units was recently studied experimentally
by NMR (RSC Advances, 2019, 9, 18018) and tested as gene carrier successfully (Int. J …

Size and Structure of Empty and Filled Nanocontainer Based on Peptide Dendrimer with Histidine Spacers at Different pH

VV Bezrodnyi, SE Mikhtaniuk, OV Shavykin, IM Neelov… - Molecules, 2021 - mdpi.com
Novel peptide dendrimer with Lys-2His repeating units was recently synthesized, studied by
NMR (Molecules, 2019, 24, 2481) and tested as a nanocontainer for siRNA delivery (Int. J …