Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Abstract Iron–sulphur (Fe–S) clusters are inorganic cofactors that are found in nearly all
species and are composed of various combinations of iron and sulphur atoms. Fe–S clusters …

Iron–sulfur (Fe–S) clusters are prosthetic groups of proteins biosynthesized on scaffold
proteins by highly conserved multi-protein machineries. Biosynthesis of Fe–S clusters into …

Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased
expression of frataxin, a mitochondrial protein that stimulates iron–sulfur (Fe-S) cluster …

Iron sulfur (Fe-S) clusters, preassembled on the ISCU scaffold, are transferred to target
proteins or to intermediate scaffolds by a dedicated chaperone-cochaperone system …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Ferredoxins play an important role as an electron donor in iron–sulfur (Fe–S) cluster
biosynthesis. Two ferredoxins, human mitochondrial ferredoxin 1 (FDX1) and human …

The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …

The major classes of molecular chaperones have highly variable sequences, sizes, and
shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their …