The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

Osteosarcoma, a bone cancer usually seen in children and young adults, is generally a high-
grade malignancy presented by extreme metastases to the lungs. Osteosarcoma has a …

As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

Osteosarcoma patient survival has remained stagnant for 30 years. Novel therapeutic
approaches are needed to improve outcomes. We examined the expression of Programmed …

The identification of subtype-specific translocations has revolutionized the diagnostics of
sarcoma and has provided new insight into oncogenesis. We used RNA-seq to investigate …

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …

Osteosarcoma is a relatively uncommon cancer, accounting for 5% of childhood cancers
and 8.9% of cancer-related deaths in children. The overall incidence is five cases per million …

The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …

Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …