Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Sepsis is a disease characterized by multiple organ failure caused by immune
hyperactivation and cytokine storms. Studies have shown that the incidence of sepsis in …

Lipid nanoparticles (LNPs) are important delivery systems for RNA-based therapeutics, yet
the mechanism of their interaction with endosomal membranes remains unclear. Here, the …

The emulsion/evaporation method represents a pivotal approach to synthesize nanogels for
controlled drug delivery. However, this strategy is constrained to the use of at least one …

Abstract “Foreignization” of tumor cells via delivery of a non-self foreign antigen (Ag) into
tumors is an appealing strategy to initiate anti-tumor immunity that can facilitate tumor …

Intense and persistent oxidative stress, excessive inflammation, and impaired angiogenesis
severely hinder diabetic wound healing. Bioactive hydrogel dressings with …

Drug delivery plays a crucial part in medical therapy, where stimuli-responsive nanocarriers
exhibit high delivery efficacy through changing their physicochemical properties in response …

There is a growing demand of bioinspired wound-healing platforms with superior tissue
repairing and low immunogenicity. Hyaluronic acid (HA) and sericin (Sc) are extensively …

Cancer has been conceptualized as a chronic wound with a predominance of tumor
promoting inflammation. Given the accumulating evidence that the microenvironment …