Advances in the syntheses of quinoline and quinoline-annulated ring systems

S Madapa, Z Tusi, S Batra - Current Organic Chemistry, 2008 - ingentaconnect.com
Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …

Microwave irradiation for the synthesis of quinoline scaffolds: a review

MS Tople, NB Patel, PP Patel - Journal of the Iranian Chemical Society, 2023 - Springer
This review article provides a detailed overview of the microwave-assisted synthesis of
quinoline and its derivatives. Traditional synthetic techniques require the utilisation of costly …

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

B Baragaña, NR Norcross, C Wilson… - Journal of medicinal …, 2016 - ACS Publications
The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-
carboxamides are described. This series was identified from a phenotypic screen against …

Pfitzinger reaction in the synthesis of bioactive compounds-a review

JN Sangshetti, AS Zambare, I Gonjari… - Mini-Reviews in …, 2014 - ingentaconnect.com
Pfitzinger reaction is the formation of derivative of 4-quinoline carboxylic acids from isatins or
its analogs under alkaline condition. This reaction was first discovered by Pfitzinger at the …

Two novel dicarboxylic acid derivatives and a new dimeric hydrolyzable tannin from walnuts

H Ito, T Okuda, T Fukuda, T Hatano… - Journal of agricultural …, 2007 - ACS Publications
In addition to the 16 previously reported polyphenols including 3 new ellagitannins, 2 novel
dicarboxylic acid derivatives, glansreginins A (1) and B (2), and a new dimeric hydrolyzable …

[HTML][HTML] Molecular modelling studies for 4-oxo-1, 4-dihydroquinoline-3-carboxamide derivatives as anticancer agents

SS Kapale, SN Mali, HK Chaudhari - Medicine in Drug Discovery, 2019 - Elsevier
The ligand library reporting anticancer activities was taken from literature containing forty-
two 4-oxo-1, 4-dihydroquinoline-3-carboxamides derivatives and was thoroughly …

2-(Alkylthio)-3-(Naphthalen-1-yl)Quinazolin-4(3H)-Ones: Ultrasonic Synthesis, DFT and Molecular Docking Aspects

FF Mohammed, M Hagar, S Parveen… - Polycyclic Aromatic …, 2022 - Taylor & Francis
(Naphthalen-1-yl)-2-thioxo-2, 3-dihydroquinazolin-4 (1 H)-one 1, and its S-alkylated
products 2–6, were effectively synthesized under ultrasonic irradiation under greener …

Reaction of isatins with 6-amino uracils and isoxazoles: isatin ring-opening vs. annulations and regioselective synthesis of isoxazole fused quinoline scaffolds in water

N Poomathi, S Mayakrishnan, D Muralidharan… - Green …, 2015 - pubs.rsc.org
A green and efficient straightforward approach for the regioselective synthesis of novel 6-
amino-5-(3-phenylisoxazolo [5, 4-b] quinolin-4-yl) pyrimidine-2, 4 (1H, 3H)-diones and 3 …

(Benzylideneamino)triazole–Thione Derivatives of Flurbiprofen: An Efficient Microwave-Assisted Synthesis and In Vivo Analgesic Potential

M Zaheer, M Zia-ur-Rehman, R Munir, N Jamil… - ACS …, 2021 - ACS Publications
Triazole is an imperative heterocycle renowned for its broad-spectrum biological
significance. In this manuscript, facile microwave-assisted synthesis of a series of 4 …

Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2 (1H)-ones as potential TACE inhibitors: design, synthesis, molecular modeling, and preliminary …

S DasGupta, PR Murumkar, R Giridhar… - Bioorganic & medicinal …, 2009 - Elsevier
Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2 (1H)-
ones were synthesized and evaluated for their TACE inhibitory activity. Most of the …