ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

Standardized variant curation is essential for clinical care recommendations for patients with
inherited disorders. Clinical Genome Resource (ClinGen) variant curation expert panels are …

Among their diverse roles as transcriptional regulators during development and cell fate
specification, the RUNX transcription factors are best known for the parts they play in …

During ontogeny, hematopoietic stem and progenitor cells arise from hemogenic
endothelium through an endothelial-to-hematopoietic transition that is strictly dependent on …

The broad use of next-generation sequencing and microarray platforms in research and
clinical laboratories has led to an increasing appreciation of the role of germline mutations in …

Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of
hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we …

RUNX1 is an important transcription factor for hematopoiesis. There are multiple
alternatively spliced isoforms of RUNX1. The best known isoforms are RUNX1a from use of …

RUNX1 is a transcription factor that plays key roles in hematopoietic development and in
hematopoiesis and lymphopoiesis. In this article, we report that RUNX1 regulates a gene …

The frequency of germline RUNX1 variants in an unselected acute myeloid leukemia (AML)
population is poorly defined and likely underestimated. The recent study by Simon et al1 is …