Vibrational circular dichroism (VCD) spectroscopy has become an important part of the
(stereo-) chemists' toolbox as a reliable method for the determination of absolute …

Chirality plays a crucial role in drug discovery and development. As a result, a significant
number of commercially available drugs are structurally dissymmetric and enantiomerically …

Abstract Vibrational Circular Dichroism (VCD) spectra often differ strongly from one
conformer to another, even within the same absolute configuration of a molecule. Simulated …

With the rapid development of high performance computers and computational methods,
including software, an increasing number of experimental chemists have tried to use …

Cyclic peptides are privileged structures in medicinal chemistry; however, their solution-state
structure characterization is difficult. Vibrational circular dichroism (VCD) spectroscopy is a …

We report the IR and VCD spectra of azithromycin, a macrolide antibiotic with a total of 18
stereogenic centers. The computational analysis of the spectra reveals that a single water …

Utilizing experimental and computational vibrational circular dichroism (VCD) spectroscopy,
we explored the conformational preferences of a series of chiral C3‐symmetric …

Chiral analysis has become a crucial step in studying the stereospecific synthesis of Active
Pharmaceutical Ingredients (APIs). Both Vibrational Circular Dichroism (VCD) and Molecular …

Orbitides are bioactive head-to-tail natural cyclic peptides from plant species. Their
bioactivity is intrinsically related to the main conformations adopted in solution, whose …

Carbamate is an emerging class of a polymer backbone for constructing sequence-defined,
abiotic polymers. It is expected that new functional materials can be de novo designed by …