Cellular senescence is a state of cell cycle arrest induced by several forms of metabolic
stress. Senescent cells accumulate with advancing age and have a distinctive phenotype …

With the extension of life span over the past several decades, the age-related loss of muscle
mass and strength that characterizes sarcopenia is becoming more evident and thus, has a …

Pharmacologic activation of branched-chain amino acid (BCAA) catabolism is protective in
models of heart failure (HF). How protection occurs remains unclear, although a causative …

The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic
diseases based on its reported actions in the liver and skeletal muscle. We evaluated two …

Objective Skeletal muscle insulin signaling is a major determinant of muscle growth and
glucose homeostasis. Protein kinase B/Akt plays a prominent role in mediating many of the …

Satellite cells (SCs) reside in a dormant state during tissue homeostasis. The specific
paracrine agents and niche cells that maintain SC quiescence remain unknown. We find that …

Reactive oxygen species (ROS) generated during exercise are considered integral for the
health-promoting effects of exercise. However, the precise mechanisms by which exercise …

Given the numerous health benefits of exercise, understanding how exercise capacity is
regulated is a question of paramount importance. Circulating interleukin 6 (IL-6) levels surge …

It is well known that an increase in mechanical loading can induce skeletal muscle
hypertrophy, and a long standing model in the field indicates that mechanical loads induce …

Background Diabetes is the seventh leading cause of death in the USA, and disruption of
circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This …