Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

Most metazoan microRNA (miRNA) target sites have perfect pairing to the seed region,
located near the miRNA 5′ end. Although pairing to the 3′ region sometimes supplements …

MicroRNAs (miRNAs) function as 21–24 nucleotide guide RNAs that use partial base-
pairing to recognize target messenger RNAs and repress their expression. As a large …

A well-defined mechanism governs the maturation of most microRNAs (miRNAs) in animals,
via stepwise cleavage of precursor hairpin transcripts by the Drosha and Dicer RNase III …

MicroRNAs (miRNAs) are a class of∼ 22 nt non-coding RNAs that control diverse biological
functions in animals, plants and unicellular eukaryotes by promoting degradation or …

A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …