Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Transient receptor potential channels in the vasculature
S Earley, JE Brayden - Physiological reviews, 2015 - journals.physiology.org
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure
Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …
by the diameter of small arteries and arterioles, the contractility of which is regulated by …
Animal models in cardiovascular research: hypertension and atherosclerosis
Hypertension and atherosclerosis are among the most common causes of mortality in both
developed and developing countries. Experimental animal models of hypertension and …
developed and developing countries. Experimental animal models of hypertension and …
Endothelium-dependent hyperpolarization (EDH) in hypertension: the role of endothelial ion channels
K Goto, T Ohtsubo, T Kitazono - International Journal of Molecular …, 2018 - mdpi.com
Upon stimulation with agonists and shear stress, the vascular endothelium of different
vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin …
vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin …
Endogenous miR-204 protects the kidney against chronic injury in hypertension and diabetes
Y Cheng, D Wang, F Wang, J Liu… - Journal of the …, 2020 - journals.lww.com
Background Aberrant microRNA (miRNA) expression affects biologic processes and
downstream genes that are crucial to CKD initiation or progression. The miRNA miR-204-5p …
downstream genes that are crucial to CKD initiation or progression. The miRNA miR-204-5p …
[HTML][HTML] Transient receptor potential channels and endothelial cell calcium signaling
The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …
endothelium has a number of functions including the control of blood vessels diameter …
Structural determinants of 5′, 6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
A Berna-Erro, M Izquierdo-Serra, RV Sepúlveda… - Scientific reports, 2017 - nature.com
TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic
acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium …
acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium …
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A–mediated phosphorylation
Transient receptor potential vanilloid 4 (TRPV4) is a Ca 2+-permeable channel of the
transient receptor potential (TRP) superfamily activated by diverse stimuli, including warm …
transient receptor potential (TRP) superfamily activated by diverse stimuli, including warm …