Corticostriatal connectivity and its role in disease

GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Deep brain stimulation mechanisms: beyond the concept of local functional inhibition

JM Deniau, B Degos, C Bosch… - European Journal of …, 2010 - Wiley Online Library
Deep brain electrical stimulation has become a recognized therapy in the treatment of a
variety of motor disorders and has potentially promising applications in a wide range of …

Prefrontal-subthalamic hyperdirect pathway modulates movement inhibition in humans

W Chen, C de Hemptinne, AM Miller, M Leibbrand… - Neuron, 2020 - cell.com
The ability to dynamically change motor outputs, such as stopping an initiated response, is
an important aspect of human behavior. A hyperdirect pathway between the inferior frontal …

Optical deconstruction of parkinsonian neural circuitry

V Gradinaru, M Mogri, KR Thompson, JM Henderson… - science, 2009 - science.org
Deep brain stimulation (DBS) is a therapeutic option for intractable neurological and
psychiatric disorders, including Parkinson's disease and major depression. Because of the …

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

W Menegas, JF Bergan, SK Ogawa, Y Isogai… - elife, 2015 - elifesciences.org
Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet
imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to …

[HTML][HTML] Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging

C Lambert, L Zrinzo, Z Nagy, A Lutti, M Hariz, T Foltynie… - Neuroimage, 2012 - Elsevier
The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the
diencephalon. A critical component of normal motor function, it has become a key target for …

Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex

Q Li, Y Ke, DCW Chan, ZM Qian, KKL Yung, H Ko… - Neuron, 2012 - cell.com
Much recent discussion about the origin of Parkinsonian symptoms has centered around the
idea that they arise with the increase of beta frequency waves in the EEG. This activity may …

Cortical potentials evoked by subthalamic stimulation demonstrate a short latency hyperdirect pathway in humans

S Miocinovic, C de Hemptinne, W Chen… - Journal of …, 2018 - Soc Neuroscience
A monosynaptic projection from the cortex to the subthalamic nucleus is thought to have an
important role in basal ganglia function and in the mechanism of therapeutic subthalamic …

The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: a single-axon tracing study in the rat

T Kita, H Kita - Journal of Neuroscience, 2012 - Soc Neuroscience
The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and
these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been …

[HTML][HTML] Evoked potentials generated by deep brain stimulation for Parkinson's disease

J Dale, SL Schmidt, K Mitchell, DA Turner, WM Grill - Brain stimulation, 2022 - Elsevier
Background and objectives The goal of this review is to describe the general features,
mechanisms, technical recording factors, and clinical applications of brain evoked potentials …