The close relationship between chromatin and metabolism has been well-studied in recent
years. Many metabolites have been found to be cofactors used to modify chromatin, and …

A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas,
and waste exchanges between the maternal and fetal circulations and is an important …

It is increasingly appreciated that intracellular pH changes are important biological signals.
This motivates the elucidation of molecular mechanisms of pH sensing. We determined that …

In the past decade, numerous epigenetic mechanisms have been discovered to be
associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin …

Sterol response element binding protein (SREBP) is a master regulator of cellular
lipogenesis. One key step in the regulation of SREBP activity is its sequential cleavage and …

Chromatin remodelers such as the SWI/SNF complex coordinate metazoan development
through broad regulation of chromatin accessibility and transcription, ensuring normal cell …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. We previously
identified fibrogenic mesenchymal progenitor cells (MPCs) in the lungs of patients with IPF …

High mobility group protein B1 (HMGB1), a highly conserved non-histone nuclear protein, is
highly expressed in fibrotic diseases; however, the role of HMGB1 in pulmonary fibrosis has …

Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory
cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity …

The aberrant function of ATP-dependent chromatin remodeler INO80 has been implicated in
multiple types of cancers by altering chromatin architecture and gene expression; however …