Cationic liposomes as vectors for nucleic acid and hydrophobic drug therapeutics

KK Ewert, P Scodeller, L Simón-Gracia, VM Steffes… - Pharmaceutics, 2021 - mdpi.com
Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications
as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA …

Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update

E Bayraktar, R Bayraktar, H Oztatlici… - Non-coding RNA, 2023 - mdpi.com
Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …

Non-viral gene therapy: Gains and challenges of non-invasive administration methods

M Foldvari, DW Chen, N Nafissi, D Calderon… - Journal of Controlled …, 2016 - Elsevier
Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

Targeted liposomes: A nonviral gene delivery system for cancer therapy

MT Luiz, JAP Dutra, LB Tofani, JTC de Araújo… - Pharmaceutics, 2022 - mdpi.com
Cancer is the second most frequent cause of death worldwide, with 28.4 million new cases
expected for 2040. Despite de advances in the treatment, it remains a challenge because of …

Toroidal triblock copolymer assemblies

DJ Pochan, Z Chen, H Cui, K Hales, K Qi, KL Wooley - Science, 2004 - science.org
A stable phase of toroidal, or ringlike, supramolecular assemblies was formed by combining
dilute solution characteristics critical for both bundling of like-charged biopolymers and block …

Vesicular systems: an overview

S Biju, S Talegaonkar, P Mishra, R Khar - Indian journal of …, 2006 - go.gale.com
There has been keen interest in the development of a novel drug delivery system. Novel
drug delivery system aims to deliver the drug at a rate directed by the needs of the body …

Lipoplex morphologies and their influences on transfection efficiency in gene delivery

B Ma, S Zhang, H Jiang, B Zhao, H Lv - Journal of Controlled Release, 2007 - Elsevier
Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …

Nonbilayer phase of lipoplex–membrane mixture determines endosomal escape of genetic cargo and transfection efficiency

IS Zuhorn, U Bakowsky, E Polushkin, WH Visser… - Molecular therapy, 2005 - cell.com
Cationic lipids are widely used for gene delivery, and inclusion of
dioleoylphosphatidylethanolamine (DOPE) as a helper lipid in cationic lipid–DNA …

[HTML][HTML] Genetically modified mesenchymal stromal cells in cancer therapy

EK Sage, RM Thakrar, SM Janes - Cytotherapy, 2016 - Elsevier
The cell therapy industry has grown rapidly over the past 3 decades, and multiple clinical
trials have been performed to date covering a wide range of diseases. The most frequently …

[HTML][HTML] The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine

S Mochizuki, N Kanegae, K Nishina… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Gene therapy is expected to treat various incurable diseases including viral infections,
autoimmune disorders, and cancers. Cationic lipids (CL) have been used as carriers of …