The bigger picture: Why oral mucosa heals better than skin

M Waasdorp, BP Krom, FJ Bikker, PPM van Zuijlen… - Biomolecules, 2021 - mdpi.com
Wound healing is an essential process to restore tissue integrity after trauma. Large skin
wounds such as burns often heal with hypertrophic scarring and contractures, resulting in …

Oral-gut microbiome axis in the pathogenesis of cancer treatment-induced oral mucositis

G Al-Qadami, Y Van Sebille, J Bowen… - Frontiers in Oral …, 2022 - frontiersin.org
Oral mucositis (OM) is one of the most common and debilitating oral complications of cancer
treatments including chemotherapy, radiotherapy, and hematopoietic stem cell …

The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

L Yu, N Maishi, E Akahori, A Hasebe, R Takeda… - Cancer …, 2022 - Wiley Online Library
Recent studies have demonstrated a relationship between oral bacteria and systemic
inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and …

Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral …

F Geng, J Liu, Y Guo, C Li, H Wang, H Wang… - Frontiers in cellular …, 2017 - frontiersin.org
Recent epidemiological studies revealed a significant association between oral squamous
cell carcinoma (OSCC) and Porphyromonas gingivalis, a major pathogen of periodontal …

The periodontal stem/progenitor cell inflammatory‐regenerative cross talk: A new perspective

KM Fawzy El‐Sayed, M Elahmady… - Journal of …, 2019 - Wiley Online Library
Adult multipotent stem/progenitor cells, with remarkable regenerative potential, have been
isolated from various components of the human periodontium. These multipotent …

Microbial changes in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients

AMGA Laheij, JE Raber-Durlacher… - Scientific reports, 2019 - nature.com
The aim of this prospective, two center study was to investigate the dynamics of the microbial
changes in relation to the development of ulcerative oral mucositis in autologous SCT …

Mucosal and salivary microbiota associated with recurrent aphthous stomatitis

Y Kim, YS Choi, KJ Baek, SH Yoon, HK Park, Y Choi - BMC microbiology, 2016 - Springer
Background Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder of
unclear etiopathogenesis. Although recent studies of the oral microbiota by high-throughput …

Mucositis and infection in hematology patients

NMA Blijlevens, CEM de Mooij - International Journal of Molecular …, 2023 - mdpi.com
Survival in patients with hematological malignancies has improved over the years, both due
to major developments in anticancer treatment, as well as in supportive care. Nevertheless …

Can the oral microflora affect oral ulcerative mucositis?

AMGA Laheij, JJ de Soet - Current opinion in supportive and …, 2014 - journals.lww.com
We come to realize that some diseases are associated with a shift in the microflora. The role
of the microflora in oral and intestinal mucositis is gaining more attention in recent literature …

α‐tocopherol decreases interleukin‐1β and‐6 and increases human β‐defensin‐1 and‐2 secretion in human gingival fibroblasts stimulated with Porphyromonas …

A Derradjia, H Alanazi, HJ Park… - Journal of …, 2016 - Wiley Online Library
Background and Objective Periodontitis, a disease associated with chronic inflammation,
results in significant destruction of periodontal tissues. Uncontrolled, periodontal disease …