Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system
M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …
Searching for peripheral biomarkers in neurodegenerative diseases: the tryptophan-kynurenine metabolic pathway
Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …
which develops into a certain clinical picture. The pathogenesis and disease course vary …
Memory enhancement with kynurenic acid and its mechanisms in neurotransmission
Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess
neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and …
neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and …
The kynurenine pathway in major depression: What we know and where to next
Major depression is a serious psychiatric disorder, occurring in up to 20% of the population.
Despite its devastating burden, the neurobiological changes associated with depression are …
Despite its devastating burden, the neurobiological changes associated with depression are …
Monitoring the redox status in multiple sclerosis
Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial
demyelinating disease of the central nervous system. MS is characterized by a wide range of …
demyelinating disease of the central nervous system. MS is characterized by a wide range of …
[HTML][HTML] The tryptophan catabolite or kynurenine pathway in major depressive and bipolar disorder: A systematic review and meta-analysis
AF Almulla, Y Thipakorn, A Vasupanrajit… - Brain, behavior, & …, 2022 - Elsevier
Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …
Crosstalk between existential phenomenological psychotherapy and neurological sciences in mood and anxiety disorders
Psychotherapy is a comprehensive biological treatment modifying complex underlying
cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with …
cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with …
Co-players in chronic pain: neuroinflammation and the tryptophan-kynurenine metabolic pathway
Chronic pain is an unpleasant sensory and emotional experience that persists or recurs
more than three months and may extend beyond the expected time of healing. Recently …
more than three months and may extend beyond the expected time of healing. Recently …
The role of tryptophan dysmetabolism and quinolinic acid in depressive and neurodegenerative diseases
K Hestad, J Alexander, H Rootwelt, JO Aaseth - Biomolecules, 2022 - mdpi.com
Emerging evidence suggests that neuroinflammation is involved in both depression and
neurodegenerative diseases. The kynurenine pathway, generating metabolites which may …
neurodegenerative diseases. The kynurenine pathway, generating metabolites which may …
The footprint of kynurenine pathway in neurodegeneration: Janus-faced role in Parkinson's disorder and therapeutic implications
T Behl, I Kaur, A Sehgal, S Singh, S Bhatia… - International Journal of …, 2021 - mdpi.com
Progressive degeneration of neurons and aggravation of dopaminergic neurons in the
substantia nigra pars compacta results in the loss of dopamine in the brain of Parkinson's …
substantia nigra pars compacta results in the loss of dopamine in the brain of Parkinson's …