Rac1: A regulator of cell migration and a potential target for cancer therapy

N Ma, E Xu, Q Luo, G Song - Molecules, 2023 - mdpi.com
Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐Dependent transcriptional program

M Huang, W Dong, R Xie, J Wu, Q Su… - Cancer …, 2022 - Wiley Online Library
Background Lymphatic metastasis has been associated with poor prognosis in bladder
cancer patients with limited therapeutic options. Emerging evidence shows that heat shock …

New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials

P He, Q Dai, X Wu - Environmental Research, 2023 - Elsevier
A high number of cancer-related deaths (up to 90) are due to metastasis and simple
definition of metastasis is new colony formation of tumor cells in a secondary site. In tumor …

The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment

B Cheng, L Li, Y Wu, T Luo, C Tang, Q Wang, Q Zhou… - Cell & Bioscience, 2023 - Springer
Background Prostate cancer is a leading cause of cancer-related deaths among men
worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in …

CRISPR genome-wide screening identifies PAK1 as a critical driver of ARSI cross-resistance in prostate cancer progression

H Chen, K Dong, J Ding, J Xia, F Qu, F Lan, H Liao… - Cancer Letters, 2024 - Elsevier
Next-generation androgen receptor signaling inhibitors (ARSIs), such as enzalutamide
(Enza) and darolutamide (Daro), are initially effective for the treatment of advanced prostate …

TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination

Q Zhou, X Chen, K Yao, Y Zhang, H He… - Journal of Experimental …, 2023 - Springer
Background Bone metastasis is a principal cause of mortality in patients with prostate cancer
(PCa). Increasing evidence indicates that high expression of stromal interaction molecule 1 …

DEPDC1B promotes melanoma angiogenesis and metastasis through sequestration of ubiquitin ligase CDC16 to stabilize secreted SCUBE3

F Hu, KO Fong, MPL Cheung, JA Liu, R Liang… - Advanced …, 2022 - Wiley Online Library
The ability of melanoma to acquire metastasis through the induction of angiogenesis is one
of the major causes of skin cancer death. Here, it is found that high transcript levels of DEP …

Glutathione-sensitive nanoparticles enhance the combined therapeutic effect of checkpoint kinase 1 inhibitor and cisplatin in prostate cancer

S Peng, X Zhang, H Huang, B Cheng, Z Xiong… - APL …, 2022 - pubs.aip.org
Prostate cancer (PCa) is the second most common malignant tumor among males.
Traditional treatments for PCa, which include surgery and endocrine therapy, have shown …

Targeting the Rac1 pathway for improved prostate cancer therapy using polymeric nanoparticles to deliver of NSC23766

Z Li, J Huang, T Du, Y Lai, K Li, ML Luo, D Zhu… - Chinese Chemical …, 2022 - Elsevier
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. The Rac1-
GTP inhibitor NSC23766 has been shown to suppress PCa growth. However, these …

Targeting P21-activated kinase-1 for metastatic prostate cancer

PR Somanath, J Chernoff, BS Cummings, SM Prasad… - Cancers, 2023 - mdpi.com
Simple Summary Metastatic prostate cancer (mPCa) results in high mortality and there are
no effective treatments. The molecular mechanisms mediating the transition of early-stage …