Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …

The updated 2016 edition of the World Health Organization (WHO) Classification of Tumours
of the Central Nervous System (CNS) uses molecular parameters and the histology to define …

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children
and young adults, often with a history of epilepsy. While the genetic profiles of common …

Abstract Background. Diffuse H3 K27M-mutant gliomas occur primarily in children but can
also be encountered in adults. The aim of this study was to describe the characteristics of H3 …

Simple Summary Glioblastoma is the most common malignant primary brain tumor in adults.
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …

Diffuse intrinsic pontine glioma (DIPG) has proven to be one of the most challenging of all
pediatric cancers. Owing to a historical reticence to obtain tumor tissue for study, and based …

Hypoxia and inflammation are implicated in the episodic induction of heterotopic
endochondral ossification (HEO); however, the molecular mechanisms are unknown. HIF …

Neurotrophins and their receptors are frequently expressed in malignant gliomas, yet their
functions are largely unknown. Previously, we have shown that p75 neurotrophin receptor is …

The NTRK1 gene encodes Tropomyosin-related kinase A (TRKA), the high-affinity Nerve
Growth Factor Receptor. NTRK1 was originally isolated from a colorectal carcinoma (CRC) …

Studies in pediatric high-grade astrocytomas (HGA) by our group and others have
uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) …