Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the
last decades demonstrated promising biological activities by the virtue of their great diversity …

Regulatory T cells (Tregs) are a subpopulation of CD4+ T cells that are essential for
maintaining the homeostasis of the immune system, limiting self-reactivity and excessive …

Single-cell sequencing technologies have noteworthily improved our understanding of the
genetic map and molecular characteristics of bladder cancer (BC). Here we identify CD39 as …

The combination of reactive oxygen species‐involved chemodynamic therapy (CDT) and
photothermal therapy (PTT) holds great promise in enhancing anticancer effects. Herein, a …

BACKGROUND & AIMS: Adenosine mediates immune suppression and is generated by the
ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial …

Alzheimer s disease (AD) is the most common form of dementia. It is characterized by
cerebral extracellular amyloid plaques and intracellular neurofibrillary tangles.[1] Although …

P2 receptors that are activated by extracellular nucleotides (eg, ATP, ADP, UTP, UDP, Ap n
A) and P1 receptors activated by adenosine control a diversity of biological processes. The …

In the tumor microenvironment, unusually high concentrations of extracellular adenosine
promote tumor proliferation through various immunosuppressive mechanisms. Blocking …

Extracellular adenosine has been implicated as anti‐inflammatory signaling molecule
during acute lung injury (ALI). The main source of extracellular adenosine stems from a …

Protein kinase CK2 is a multifunctional kinase of medical importance that is dysregulated in
many cancers. In this study, polyoxometalates were identified as original CK2 inhibitors.[P 2 …