Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Natural killer cells: from innate to adaptive features

AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory

T Rückert, CA Lareau, MF Mashreghi, LS Ludwig… - Nature …, 2022 - nature.com
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

[HTML][HTML] A physical wiring diagram for the human immune system

J Shilts, Y Severin, F Galaway, N Müller-Sienerth… - Nature, 2022 - nature.com
The human immune system is composed of a distributed network of cells circulating
throughout the body, which must dynamically form physical associations and communicate …

The broad spectrum of human natural killer cell diversity

AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

Immunometabolism and natural killer cell responses

KL O'Brien, DK Finlay - Nature Reviews Immunology, 2019 - nature.com
Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune
responses to tumours and viral infection. However, in certain chronic diseases, including …

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

Q Hammer, T Rückert, EM Borst, J Dunst… - Nature …, 2018 - nature.com
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …

Human NK cells, their receptors and function

L Quatrini, M Della Chiesa, S Sivori… - European journal of …, 2021 - Wiley Online Library
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …

Human NK cells: From development to effector functions

AS Perera Molligoda Arachchige - Innate immunity, 2021 - journals.sagepub.com
NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Characterizing the dysfunctional NK cell: assessing the clinical relevance of exhaustion, anergy, and senescence

SJ Judge, WJ Murphy, RJ Canter - Frontiers in cellular and infection …, 2020 - frontiersin.org
There is a growing body of literature demonstrating the importance of T cell exhaustion in
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …