Fibrosis is a common occurrence following organ injury and failure. To date, there is no
effective treatment for this condition. Melatonin targets numerous molecular pathways, a …

Melatonin, a pineal hormone, is well known to regulate the sleep–wake cycle. Besides, the
hormone has been shown to display pleiotropic effects arising from its powerful anti-oxidant …

Accumulating evidence suggests that the pineal hormone melatonin displays protective
effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we …

Cyclosporine A (CsA) use is associated with several side effects, the most important of which
is nephrotoxicity that includes, as we previously showed, tubular injury and interstitial …

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a
potential responsible mechanism. Therefore, we aimed to investigate the protective role of …

Abstract Effect of vanadyl acetylacetonate (VAc), tungstate and molybdate on
gluconeogenesis has been studied in isolated hepatocytes and kidney-cortex tubules. In …

Objectives: The health impact of melatonin cannot be overemphasized. The therapeutic
input of melatonin on nephrotoxicity was explained. Experimental approach: Search engines …

Cyclosporine A (CsA) is a drug used in autoimmune disorders and organ transplantations.
Omega 3 fatty acids (O-3) and sesame oil (SO) have antioxidant properties. We aimed to …

Melatonin, a widespread physiological mediator, has been demonstrated to exhibit a dose‑
dependent immunoregulatory effect in vitro and in vivo, including mediating physiological …

Phyllanthus niruri (Euphorbiaceae) is a popular plant in folk medicine, whole plant, fresh
leaves, and fruits are used in the treatment of various diseases. In the present study …