Massively parallel sample preparation for multiplexed single-cell proteomics using nPOP
Single-cell proteomics by mass spectrometry (MS) allows the quantification of proteins with
high specificity and sensitivity. To increase its throughput, we developed nano-proteomic …
high specificity and sensitivity. To increase its throughput, we developed nano-proteomic …
Data-independent acquisition shortens the analytical window of single-cell proteomics to fifteen minutes in capillary electrophoresis mass spectrometry
Separation in single-cell mass spectrometry (MS) improves molecular coverage and
quantification; however, it also elongates measurements, thus limiting analytical throughput …
quantification; however, it also elongates measurements, thus limiting analytical throughput …
Next-Generation Cancer Phenomics: A Transformative Approach to Unraveling Lung Cancer Complexity and Advancing Precision Medicine
S Dasgupta - OMICS: A Journal of Integrative Biology, 2024 - liebertpub.com
Lung cancer remains one of the leading causes of cancer-related deaths globally, with its
complexity driven by intricate and intertwined genetic, epigenetic, and environmental factors …
complexity driven by intricate and intertwined genetic, epigenetic, and environmental factors …
Single-cell proteomics of Arabidopsis leaf mesophyll identifies drought stress-related proteins
The application of single-cell omics tools to biological systems can provide unique insights
into diverse cellular populations and their heterogeneous responses to internal and external …
into diverse cellular populations and their heterogeneous responses to internal and external …
DESP demixes cell-state profiles from dynamic bulk molecular measurements
Understanding the dynamic expression of proteins and other key molecules driving
phenotypic remodeling in development and pathobiology has garnered widespread interest …
phenotypic remodeling in development and pathobiology has garnered widespread interest …
[HTML][HTML] Inferring post-transcriptional regulation within and across cell types in human testis
Single-cell tissue atlases commonly use RNA abundances as surrogates for protein
abundances. Yet, protein abundance also depends on the regulation of protein synthesis …
abundances. Yet, protein abundance also depends on the regulation of protein synthesis …
Single-Cell Proteomic and Transcriptomic Characterization of Drug-Resistant Prostate Cancer Cells Reveals Molecular Signatures Associated with Morphological …
This study delves into the proteomic intricacies of drug-resistant cells (DRCs) within prostate
cancer, which are known for their pivotal roles in therapeutic resistance, relapse, and …
cancer, which are known for their pivotal roles in therapeutic resistance, relapse, and …
The current economics and throughput of single cell proteomics by liquid chromatography mass spectrometry
A Smythers, B Orsburn - 2024 - chemrxiv.org
Single cell proteomics by mass spectrometry (SCP) is an emerging field of study that has
captured the interest and imagination of biologists in a wide array of disciplines. In the …
captured the interest and imagination of biologists in a wide array of disciplines. In the …