Natural products generally fall into the biologically relevant chemical space and always
possess novel biological activities, thus making them a rich source of lead compounds for …

As a flavin adenine dinucleotide (FAD)-dependent monoamine oxidase, lysine specific
demethylase 1 (LSD1/KDM1A) functions as a transcription coactivator or corepressor to …

Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes.
In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate …

LSD1 was significantly over-expressed in several cancer types, and its aberrant
overexpression was revealed to play a crucial role in the initiation and progression of …

Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most
diagnosed cancer worldwide since 2020. Histone methylation is a common biological …

Many natural products can exert anticancer or chemopreventive activity by interfering with
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …

There are abundant sources of anticancer drugs in nature that have a broad prospect in
anticancer drug discovery. Natural compounds, with biological activities extracted from …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

Abstract Background Dolomiaea costus (syn: Saussurea costus; Family Asteraceae)
occupies an important place in the traditional Chinese medicinal plants and is prescribed for …

Capsaicinoids are plant secondary metabolites, and capsaicin is the main principal that
responsible to the pungency of chili peppers, with widely application as food additive. In our …