Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

Longitudinal monitoring of liver function in vivo is hindered by the lack of high-resolution non-
invasive imaging techniques. Using the anterior chamber of the mouse eye as a …

Mechanisms underlying human hepatocyte growth in development and regeneration are
incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in
absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited …

Nonalcoholic fatty liver disease, recently renamed metabolic dysfunction-associated
steatotic liver disease (MASLD), is a progressive metabolic disorder that begins with …

Organoids are miniature, highly accurate representations of organs that capture the structure
and unique functions of specific organs. Although the field of organoids has experienced …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health
epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a …

Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging
from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH), which can progress to …