Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

The affinity of single-pass transmembrane (TM) proteins for ordered membrane phases has
been reported to depend on their lipidation, TM length, and lipid accessible surface area. In …

Cholesterol is a ubiquitous component of mammalian cell membranes and affects
membrane protein function. Although cholesterol-mediated formation of ordered membrane …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

The MARTINI model is a widely used coarse-grained force field popular for its capacity to
represent a diverse array of complex biomolecules. However, efforts to simulate increasingly …

As early as the development of the fluid mosaic model for cellular membranes, researchers
began observing the telltale signs of lateral heterogeneity. Over the decades this has led to …

Lipid rafts are nanoscopic assemblies of sphingolipids, cholesterol, and specific membrane
proteins. They are believed to underlie the experimentally observed lateral heterogeneity of …

Protein association in lipid membranes is fundamental to membrane protein function and of
great biomedical relevance. All-atom and coarse-grained models have been extensively …