Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for
Alzheimer's disease (AD). Regulation of dysfunctional mitochondria through multiple …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Mitochondrial oxidative stress plays an important role in the pathogenesis of Alzheimer's
disease (AD). Recently, antioxidant therapy has been considered an effective strategy for …

Worldwide, Alzheimer's disease (AD) is the most common neurodegenerative multifactorial
disease influencing the elderly population. Nowadays, several medications, among them …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …

Background: Preclinical studies, clinical trials, and reviews suggest increasing 3', 5'-cyclic
adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) with …

Alzheimer's disease (AD) is one of the major reasons for 60-80% cases of senile dementia
occurring as a result of the accumulation of plaques and tangles in the hippocampal and …

Background Alzheimer's disease (AD) represents the common neurodegenerative disease
featured by the manifestations of cognitive impairment and memory loss. AD could be …