The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …

Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells prevent autoimmune disease,
maintain immune homeostasis and modulate immune responses during infection. To …

Several subsets of Foxp3+ regulatory T cells (T reg cells) work in concert to maintain
immune homeostasis. However, the molecular bases underlying the phenotypic and …

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

Background & Aims Vascular endothelial growth factor (VEGF)− induced angiogenesis is
implicated in fibrogenesis and portal hypertension. However, the function of VEGF in fibrosis …

Innate immune system is the first line of defence against invading pathogens that is critical
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …

Various populations of regulatory T (Treg) cells have been shown to play a central role in the
maintenance of peripheral homeostasis and the establishment of controlled immune …

NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-
classical class-I-like molecule, rather than peptides presented by conventional MHC …