Adaptive responses to hypoxia are involved in the progression of lung cancer and
pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link …

Phenotypic alterations in the lung epithelium have been widely implicated in chronic
obstructive pulmonary disease (COPD) pathogenesis, but the precise mechanisms …

Abstract signatureSearch is an R/Bioconductor package that integrates a suite of existing
and novel algorithms into an analysis environment for gene expression signature (GES) …

Idiopathic pulmonary fibrosis is a lethal lung fibroproliferative disease with limited
therapeutic options. Differential expression profiling of affected sites has been instrumental …

Organ fibrosis represents a vital health threat that substantially contributes to yearly mortality
rates. While a considerable amount of research has been conducted on fibrosis, these …

Background: The pathogenesis of life-threatening cardiopulmonary diseases such as
pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD) originates …

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
exacerbated extracellular matrix deposition that disrupts oxygen exchange. Hypoxia and its …

Background Although genome-wide association studies (GWAS) have identified many
genomic regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and …

Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of
numerous diseases. We have identified a novel function of the p53 family protein TAp73 in …

The unknown aetiology of irreversible fibrotic scarring of lung tissues in Idiopathic
Pulmonary Fibrosis (IPF) has resulted in the lack of a gold standard for disease diagnosis …