In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

Macrophages play a major role in the immune system, both as antimicrobial effector cells
and as immunoregulatory cells, which induce, suppress or modulate adaptive immune …

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

Metabolic programming is emerging as a critical mechanism to alter immune cell activation,
differentiation and function. Targeting metabolism does not completely suppress or activate …

Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for
the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Impaired diabetic wounds are serious pathophysiological complications associated with
persistent microbial infections including failure in the closure of wounds, and the cause of a …

Background Chronic inflammation is a characteristic feature of diabetic cutaneous wounds.
We sought to delineate novel mechanisms involved in the impairment of resolution of …

Nitric oxide synthases (NOSs)'(L-arginine, NADPH: oxygen oxidoreductases (nitric oxide
forming); EC 1.14. 13.39) are unique among eukaryotic enzymes in being dimeric …