Cardiomyocyte death in sepsis: mechanisms and regulation

G Zhang, D Dong, X Wan… - Molecular Medicine …, 2022 - spandidos-publications.com
Sepsis‑induced cardiac dysfunction is one of the most common types of organ dysfunction in
sepsis; its pathogenesis is highly complex and not yet fully understood. Cardiomyocytes …

[HTML][HTML] Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis

E Zechendorf, CE O'Riordan, L Stiehler… - JCI insight, 2020 - ncbi.nlm.nih.gov
Septic cardiomyopathy is a life-threatening organ dysfunction caused by sepsis.
Ribonuclease 1 (RNase 1) belongs to a group of host-defense peptides that specifically …

DAMPs released from proinflammatory macrophages induce inflammation in cardiomyocytes via activation of TLR4 and TNFR

C Neu, Y Thiele, F Horr, C Beckers, N Frank… - International Journal of …, 2022 - mdpi.com
Cardiac dysfunction is a life-threatening complication in sepsis. Upon infection and cardiac
stress, the cardiac macrophage population expands. Recruited macrophages exhibit a …

Multifunctional Cationic Hyperbranched Polyaminoglycosides that Target Multiple Mediators for Severe Abdominal Trauma Management

Y Xiao, H Fang, Y Zhu, J Zhou, Z Dai… - Advanced …, 2024 - Wiley Online Library
Trauma and its associated complications, including dysregulated inflammatory responses,
severe infection, and disseminated intravascular coagulation (DIC), continue to pose lethal …

The Influence of Heparan Sulfate on Breast Amyloidosis and the Toxicity of the Pre-fibrils Formed by β-casein

J Wang, J Liu, Q Dong, Y An, J Su, H Xie, B Sun… - The Protein Journal, 2022 - Springer
Heparan sulfate (HS) as a mediator is usually involved in both inflammation and fibrosis.
Besides, pre-fibrils are the intermediates of amyloid fibrils that usually cause cell death and …

BioModelKit–An Integrative Framework for Multi-Scale Biomodel-Engineering

MA Blätke - Journal of Integrative Bioinformatics, 2018 - degruyter.com
While high-throughput technology, advanced techniques in biochemistry and molecular
biology have become increasingly powerful, the coherent interpretation of experimental …

On the Use of Evolutionary Computation for In-Silico Medicine: Modelling Sepsis via Evolving Continuous Petri Nets

A Hallawa, E Zechendorf, Y Song, A Schmeink… - … Conference on the …, 2019 - Springer
Sepsis is one of the leading causes of death in Intensive Care Units (ICU) world-wide.
Continuous Petri Nets (CPNs) offer a promising solution in modelling its underlying complex …

On the Use of Evolutionary Computation for In-Silico Medicine: Modelling Sepsis via Evolving Continuous Petri Nets

A Peine, L Marin, G Ascheid… - … 2019, Held as Part of …, 2019 - books.google.com
Sepsis is one of the leading causes of death in Intensive Care Units (ICU) world-wide.
Continuous Petri Nets (CPNs) offer a promising solution in modelling its underlying complex …