Unlocking diversity: from simple to cutting-edge synthetic methodologies of bis (indolyl) methanes

P Teli, S Soni, S Teli, S Agarwal - Topics in Current Chemistry, 2024 - Springer
From a synthetic perspective, bis (indolyl) methanes have undergone extensive
investigation over the past two to three decades owing to their remarkable pharmacological …

Recent Advances for Synthesis of Oxazole Heterocycles via C‐H/C‐N Bond Functionalization of Benzylamines

VD Kadu - ChemistrySelect, 2022 - Wiley Online Library
The five membered heteroaromatic oxazole motifs and their scaffolds exhibit significant
pharmaceutical and biological applications. Remarkably, the high efficiency in the assembly …

Metal-free approach for imidazole synthesis via one-pot N-α-C (sp 3)–H bond functionalization of benzylamines

VD Kadu, MS Thokal, RK Godase, BC Kotali… - RSC …, 2024 - pubs.rsc.org
A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles
from the reaction of arylmethylamines and 1, 2-dicarbonyls/benzoin. The N-α-C (sp3)–H …

Synthesis, in-silico potential enzymatic target predictions, pharmacokinetics, toxicity, anti-microbial and anti-inflammatory studies of bis-(2-methylindolyl) methane …

DT Nagre, SN Mali, BR Thorat, SA Thorat… - Current Enzyme …, 2021 - ingentaconnect.com
Background: The bis (indolyl) methanes (BIMs) scaffold is reported for wide varieties of
pharmacological profiles, including antibacterial, anti-proliferative, anticancer, cytotoxic …

Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide

AS Santos, RD Ferro, N Viduedo, LB Maia… - …, 2023 - Wiley Online Library
The indole moiety is an important N‐heterocycle found in natural products, and a key
structural component of many value‐added chemicals including pharmaceuticals. In …

Visible light-assisted H4 [PW11VO40] catalysed synthesis of bis (indolyl) methanes

G Jagannivasan, GN Nair, S Haridas - Molecular Catalysis, 2023 - Elsevier
The development of novel synthetic protocols for organic transformations is a key challenge
in fine chemical synthesis. A novel light-assisted protocol for the synthesis of bis (indolyl) …

Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction

VD Kadu, GA Mali, SP Khadul, GJ Kothe - RSC advances, 2021 - pubs.rsc.org
A rapid practical process has been developed for synthesis of 2, 4, 5-trisubstituted-
imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI …

One-Pot N-α-C (sp3)–H Bond Functionalisation Cascade for the Synthesis of Polysubstituted Imidazoles

VD Kadu, NC Sankala, MG Hublikar, SI Bansode… - …, 2024 - thieme-connect.com
A one-pot eco-friendly oxidative N-α-C (sp 3)–H bond functionalisation of arylmethylamines
for the synthesis of tetrasubstituted imidazoles is demonstrated. The substrate scope of …

Graphene Acid: A Potent Carbocatalyst for the Friedel–Crafts Arylation of Aldehydes with Indoles

EM Galathri, V Hrubý, OG Mountanea… - …, 2024 - Wiley Online Library
Carbocatalysis represents a highly attractive and effective field within the realm of metal‐free
nanocatalysis, significantly advancing sustainability in synthetic chemistry. Graphene acid …

Oxone-Promoted Synthesis of Bis (indolyl) methanes from Arylmethylamines and Indoles

VD Kadu, AA Patil, PR Shendage - Journal of Molecular Structure, 2022 - Elsevier
An environmentally benign synthesis of 3, 3'-bis (indolyl) methanes (BIMs) has been
developed from arylmethylamines and indoles under aerobic condition in presence of …