Accumulating evidence from animal and human research indicate that adult hippocampal
neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

Adult neurogenesis is one of the most important mechanisms contributing to brain
development, learning, and memory. Alterations in neurogenesis underlie a wide spectrum …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of 3-to 5-day-old
blastocysts. 1-5 hESCs are characterized by a high nucleus-to-cytoplasm ratio, prominent …

The combination of biomaterials with stem cells is a promising therapeutic strategy to repair
traumatic injuries in the central nervous system, and human bone marrow mesenchymal …

Due to the severity of peripheral nerve injuries (PNI) and spinal cord injuries (SCI), treatment
options for patients are limited. In this context, biomaterials designed to promote …

Three-dimensional gel matrices provide specialized microenvironments that mimic native
tissues and enable stem cells to grow and differentiate into specific cell types. Here, we …

Recent research in tissue engineering and regenerative medicine has elucidated the
importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides …

The production and transplantation of functionally active human neurons is a promising
approach to cell therapy. Biocompatible and biodegradable matrices that effectively promote …