Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering
therapeutic compounds to cells. Their entry into the cell represents the initial step in this …

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery
vectors. Non-viral vectors have become the research interest of many researchers because …

Synthetic mRNAs can become biopharmaceutics allowing vaccination against cancer,
bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs …

The ideal nonviral vector delivers its nucleic acid cargo to a specific intracellular target.
Vectors enter cells mainly through endocytosis and are distributed to various intracellular …

Highlights•Minor modifications to polymer structure determine transfection
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …

The intracellular delivery of biologically active protein represents an important emerging
strategy for both fundamental and therapeutic applications. Here, we optimized in vitro …

In this study, magnetic core/chitosan shell Nanoparticles (NPs) containing cisplatin were
synthesized via cisplatin complexation with tripolyphosphate as the chitosan crosslinker …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

Abstract Oxidation resistance 1 (OXR1) is regarded as a critical regulator of cellular
homeostasis in response to oxidative stress. However, the role of OXR1 in the neuronal …