The melanocortin system of the hypothalamus, including the neuropeptides α-melanocyte
stimulating hormone (αMSH) and agouti-related protein (AgRP), and their receptors, the …

The salivary α-amylase is a calcium-binding enzyme that initiates starch digestion in the oral
cavity. The α-amylase genes are located in a cluster on the chromosome that includes …

Child eating self-regulation refers to behaviors that enable children to start and stop eating
in a manner consistent with maintaining energy balance. Perturbations in these behaviors …

Obesity is a multifactorial disease caused by the interaction of genetic and environmental
factors related to lifestyle aspects. It has been shown that reduced sleep is associated with …

Inactivating mutations in the melanocortin 3 receptor (Mc3r) have been described as
causing obesity in mice, but the physiologic effects of MC3R mutations in humans have …

Background Polymorphisms in genes encoding proteins of the leptin-melanocortin pathway
have been associated with obesity. The involvement of these polymorphisms with changes …

Abstract Background/Aims: To evaluate the association between allelic variants of
melanocortin receptors-3 and-4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) …

Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …

The melanocortin MC3 receptor remains the most enigmatic of the melanocortin receptors
with regard to its physiological functions. The receptor is expressed both in the CNS and in …

The prevalence of obesity calls for novel therapeutic targets. The melanocortin-3 receptor
(MC3R) has been increasingly recognized as an important regulator of energy homeostasis …