Osteocytes in bone aging: Advances, challenges, and future perspectives
Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …
response to hormones and mechanical loading. Substantial evidence have demonstrated …
Interactions between muscle and bone—where physics meets biology
M Herrmann, K Engelke, R Ebert, S Müller-Deubert… - Biomolecules, 2020 - mdpi.com
Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …
Physical forces are generated through gravity, locomotion, exercise, and external devices …
The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture
AF Van Tol, V Schemenz… - Proceedings of the …, 2020 - National Acad Sciences
Organisms rely on mechanosensing mechanisms to adapt to changes in their mechanical
environment. Fluid-filled network structures not only ensure efficient transport but can also …
environment. Fluid-filled network structures not only ensure efficient transport but can also …
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
CA Schurman, SW Verbruggen… - Proceedings of the …, 2021 - National Acad Sciences
Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …
mechanisms underlying the concurrent decline in bone mass, quality, and …
Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice
Aging diminishes bone formation engendered by mechanical loads, but the mechanism for
this impairment remains unclear. Because Wnt signaling is required for optimal loading …
this impairment remains unclear. Because Wnt signaling is required for optimal loading …
[HTML][HTML] The effect of eight weeks resistance and endurance training on some angiogenesis factors of hippocampus tissue in male wistar rats
M Sadegh Ghomi, M Kashef… - Journal of Sport and …, 2021 - joeppa.sbu.ac.ir
Purpose: One of the cause of adaptations due to exercise training is increased capillary
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …
مقایسة اثر تمرین تناوبی شدید و مقاومتی فزاینده بر بیان ژن ATF3 عضلة قلبی موش‌های صحرایی دیابتی نر
سفال منش, شهاب الدین, خالدی, ندا, رجبی… - نشریه فیزیولوژی ورزش و …, 2021 - joeppa.sbu.ac.ir
هدف: از سازوکارهای مؤثر در انجام بهتر عملکرد عضلانی در ورزشکاران، القای ظرفیت
پیش‌فعال‌سازی (PAP) در روش گرم کردن است. ازاین‌رو، پژوهش حاضر به‌منظور بررسی تأثیر گرم …
پیش‌فعال‌سازی (PAP) در روش گرم کردن است. ازاین‌رو، پژوهش حاضر به‌منظور بررسی تأثیر گرم …
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish
Exercise promotes gain in bone mass through adaptive responses of the vertebrate
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …
Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes
The adaptation of the skeleton to its mechanical environment is orchestrated by
mechanosensitive osteocytes, largely by regulating the abundance of sclerostin, a secreted …
mechanosensitive osteocytes, largely by regulating the abundance of sclerostin, a secreted …
Experience in the adaptive immunity impacts bone homeostasis, remodeling, and healing
Bone formation as well as bone healing capacity is known to be impaired in the elderly.
Although bone formation is outpaced by bone resorption in aged individuals, we hereby …
Although bone formation is outpaced by bone resorption in aged individuals, we hereby …