Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

The biggest compartment of the musculoskeletal system is the tendons and ligaments. In
particular, tendons are dense tissues connecting muscle to bone that are critical for the …

Abstract Changes in the micro-environment of fibrous connective tissue can lead to
alterations in the phenotypes of tissue-resident cells, yet the underlying mechanisms are …

Non-woven nanofibrous scaffolds have been developed for tendon graft application by
using electrospinning strategies. However, electrospun nanofibrous scaffolds face some …

Angiogenesis is crucial to facilitate tendon healing, such as delivering oxygen and nutrients,
removing waste products, and controlling immune responses. Vascular endothelial growth …

Management of flexor tendon injuries of the hand remains a major clinical problem. Even
with intricate repair, adhesion formation remains a common complication. Significant …

Angiogenesis, the process of new blood vessel formation from existing blood vessels, is a
key aspect of virtually every repair process. During wound healing an extensive, but …

Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

Scarring rather than regeneration, is an inevitable outcome of unbalanced amplifications of
inflammation‐destructive signals and atresia of the regenerative niche. However, identifying …

Tendon regeneration is still a great challenge due to its avascular structure and low self-
renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for …