Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs
Steroids are polycyclic compounds that have a wide range of biological activities. They are
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
Man-made cytotoxic steroids: exemplary agents for cancer therapy
R Bansal, PC Acharya - Chemical reviews, 2014 - ACS Publications
Cancer is one of the most dreaded diseases to haunt mankind in the world today. It is one of
the leading causes of death worldwide. Although overall cancer incidence rates in the …
the leading causes of death worldwide. Although overall cancer incidence rates in the …
In silico and in vitro studies for benzimidazole anthelmintics repurposing as VEGFR-2 antagonists: novel mebendazole-loaded mixed micelles with enhanced …
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
Antifungal Activity of Endophytic Aspergillus terreus Extract Against Some Fungi Causing Mucormycosis: Ultrastructural Study
Endophytes fungi are applied as favorable safe antifungal agents as well as natural
bioactive compounds reservoir. In the current study, the inhibitory effect of endophytic fungus …
bioactive compounds reservoir. In the current study, the inhibitory effect of endophytic fungus …
Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents
MS Nafie, MA Tantawy, GA Elmgeed - Steroids, 2019 - Elsevier
There is a pressing need to discover and develop novel drugs against cancer. With the new
era of bioinformatics, which integrates different aspects, drug development has been …
era of bioinformatics, which integrates different aspects, drug development has been …
Evaluation of antioxidant and anticancer activity of crude extract and different fractions of Chlorella vulgaris axenic culture grown under various concentrations of …
EA El-Fayoumy, SMM Shanab, HS Gaballa… - … Medicine and Therapies, 2021 - Springer
Background Chlorella vulgaris is a microalga potentially used for pharmaceutical, animal
feed, food supplement, aquaculture and cosmetics. The current study aims to study the …
feed, food supplement, aquaculture and cosmetics. The current study aims to study the …
Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR …
Worldwide, cancer is still an area with high unmet medical need. Lead optimization efforts
towards structure-based drug design were employed to discover newly synthesized hetero …
towards structure-based drug design were employed to discover newly synthesized hetero …
Synthesis, DFT calculations, In silico studies, and biological evaluation of pyrano [2, 3-c] pyrazole and pyrazolo [4′, 3′: 5, 6] pyrano [2, 3‐d] pyrimidine derivatives
An eco-friendly approach was conducted for synthesizing pyrano [2, 3-c] pyrazoles M1-M25
via a one-pot reaction of hydrazine hydrate 99%, ethyl acetoacetate or diethyl malonate …
via a one-pot reaction of hydrazine hydrate 99%, ethyl acetoacetate or diethyl malonate …
Synthesis, antimicrobial, anti-cancer and in silico studies of new urea derivatives
The reaction of an alkyl or aryl isocyanates with some primary amines in acetonitrile at room
temperature afforded the corresponding alkyl-and aryl-urea derivatives. All the prepared …
temperature afforded the corresponding alkyl-and aryl-urea derivatives. All the prepared …
Synthesis and biological evaluation of novel steroidal [17, 16-d][1, 2, 4] triazolo [1, 5-a] pyrimidines
LH Huang, YF Zheng, YZ Lu, CJ Song, YG Wang, B Yu… - Steroids, 2012 - Elsevier
The preparation of steroidal [17, 16-d][1, 2, 4] triazolo [1, 5-a] pyrimidines and their biological
evaluation as potential anticancer agents are herein reported. These novel heterosteroids …
evaluation as potential anticancer agents are herein reported. These novel heterosteroids …