The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

The heterogeneity and complex nature of Alzheimer's disease (AD) is attributed to several
genetic risk factors and molecular culprits. The slow pace and increasing failure rate of …

The social burden of dementia is remarkable since it affects some 57.4 million people all
over the world. Impairment of autophagy in age-related diseases, such as dementia …

The disease heterogeneity and little therapeutic progress in neurodegenerative diseases
justify the need for novel and effective drug discovery approaches. Drug repurposing is an …

In the intricate landscape of human biology, the mechanistic target of rapamycin (mTOR)
emerges as a key regulator, orchestrating a vast array of processes in health and disease …

New drugs introduced in the market each year, have privileged structures specifically for
anticancer targets, of which quinoline-based analogues also play an important role. This …