Background Currently, spinal cord injury (SCI) is a pathological incident that triggers several
neuropathological conditions, leading to the initiation of neuronal damage with several pro …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Methylene blue (MB) is a well-established drug with a long history of use, owing to its
diverse range of use and its minimal side effect profile. MB has been used classically for the …

Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS),
produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS …

Mitochondria play a key role in various cell processes including ATP production, Ca2+
homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective …

The treatment of stroke is limited by a short therapeutic window and a lack of effective
clinical drugs. Methylene blue (MB) has been used in laboratories and clinics since the …

Acute ischemic stroke (AIS) is a leading cause of disability and death worldwide. To date,
intravenous tissue plasminogen activator and mechanical thrombectomy have been …

Subarachnoid hemorrhage (SAH) is a serious medical problem with few effective
pharmacotherapies available, and neuroinflammation has been identified as an important …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Methylene
blue (MB) has known energy-enhancing and antioxidant properties. This study tested the …

Traumatic brain injury (TBI) leads to permanent neurological impairment, and methylene
blue (MB) exerts central nervous system neuroprotective effects. However, only one …